Osthole attenuates spinal cord ischemia–reperfusion injury through mitochondrial biogenesis–independent inhibition of mitochondrial dysfunction in rats

Yue-fei Zhou, Liang Li, Feng Feng, Hua Yuan, Da-kuan Gao, Luo-an Fu, Zhou Fei

Index: J. Surg. Res. 185(2) , 805-14, (2013)

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Abstract

Background Osthole, the main bioactive compounds isolated from the traditional Chinese medical herb broad Cnidium monnieri (L.) cusson, has been shown to exert spectrum of pharmacologic activities. The aim of this study was to investigate the potential neuroprotective effects of osthole against spinal cord ischemia–reperfusion injury in rats.