A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.
T Frew, G Powis, M Berggren, R T Abraham, C L Ashendel, L H Zalkow, C Hudson, S Qazia, E Gruszecka-Kowalik, R Merriman
Index: Anticancer Res. 14(6B) , 2425-8, (1994)
Full Text: HTML
Abstract
A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol-3-kinase (PtdIns-3-K) has been developed. Four natural product inhibitors of Ptdlns-3-K have been identified with IC50 values for hypericin 0.18 microM, emodin 3.3 microM, asperuloside 2.0 microM and uttronin A 1.1 microM.
Related Compounds
Related Articles:
Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.
2005-04-01
[J. Nat. Prod. 68 , 592-5, (2005)]
[Chemical constituents from root of Lasianthus acuminatissimus I].
2006-01-01
[Zhongguo Zhong Yao Za Zhi 31(2) , 133-5, (2006)]
[Isolation and identification of chemical constituents from Hedyotis chrysotricha (Palib.) Merr].
1992-02-01
[Zhongguo Zhong Yao Za Zhi 17(2) , 98-100, 127, (1992)]
Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni).
1999-12-01
[J. Agric. Food Chem. 47(12) , 4880-2, (1999)]
1997-01-15
[Mutat. Res. 388(1) , 7-20, (1997)]