Asperuloside

Names

[ Name ]:
Asperuloside

[Synonym ]:
[5-(Hexopyranosyloxy)-1-oxo-2a,4a,5,7b-tetrahydro-1H-2,6-dioxacyclopenta[cd]inden-4-yl]methyl acetate
Asperulosid
RUBICHLORIC ACID
ASPERULOSIDE
1H-2,6-Dioxacyclopent[cd]inden-1-one, 4-[(acetyloxy)methyl]-5-(hexopyranosyloxy)-2a,4a,5,7b-tetrahydro-

Biological Activity

[Description]:

Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. He J, et al. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018 Jul 12;19(7).

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
704.2±60.0 °C at 760 mmHg

[ Melting Point ]:
131-132°

[ Molecular Formula ]:
C₁₈H₂₂O₁₁

[ Molecular Weight ]:
414.361

[ Flash Point ]:
254.1±26.4 °C

[ Exact Mass ]:
414.116211

[ PSA ]:
161.21000

[ LogP ]:
-3.28

[ Vapour Pressure ]:
0.0±5.1 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
2-8C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.

J. Nat. Prod. 68 , 592-5, (2005)

Purification of a n-BuOH-soluble partition of the MeOH extract of Morinda citrifolia (Noni) fruits led to the isolation of two new iridoid glucosides, 6alpha-hydroxyadoxoside (1) and 6beta,7beta-epoxy...

[Chemical constituents from root of Lasianthus acuminatissimus I].

Zhongguo Zhong Yao Za Zhi 31(2) , 133-5, (2006)

To investigate the chemical constituents from the root of Lasianthus acuminatissimus of Rubiaceae.Normal, reverse phase silica gel, macroporous resin column and HPLC chromatography were used for isola...

[Isolation and identification of chemical constituents from Hedyotis chrysotricha (Palib.) Merr].

Zhongguo Zhong Yao Za Zhi 17(2) , 98-100, 127, (1992)