Helvetica Chimica Acta

Synthetic Studies on Camptothecins. Part 3

YY Kuang, JZ Niu, FE Chen

Index: Kuang, Yun-Yan; Niu, Jing-Ze; Chen, Fen-Er Helvetica Chimica Acta, 2010 , vol. 93, # 10 p. 2094 - 2099

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Abstract

Abstract A concise and efficient asymmetric process for the total synthesis of (20S)-7-ethyl- 10-hydroxycamptothecin (= SN-38; 1f), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone 4 into

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