Synthetic Communications

Scalable Synthetic Route to 2-Amino-5-hydroxypropiophenone: Efficient Formal Synthesis of Irinotecan

…, R Rao, JS Yadav, M Khagga

Index: Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667

Full Text: HTML

Citation Number: 0

Abstract

2-Amino-5-hydroxypropiophenone, a key precursor in the total synthesis of irinotecan, has been synthesized. Regioselective nitration and a SNAr displacement are the key steps involved in this strategy, which is high yielding, is economical, and has been performed on a plant scale. ... Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

Related Articles:

Synthesis and antitumor activity of 20 (S)-camptothecin derivatives: A-ring modified and 7, 10-disubstituted camptothecins.

[Chemical and Pharmaceutical Bulletin, , vol. 39, # 12 p. 3183 - 3188]

Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1

[Drug Metabolism and Disposition, , vol. 41, # 11 p. 1888 - 1895]

A General Synthetic Approach to the (20S)??Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles

[Josien, Hubert; Ko, Sung-Bo; Bom, David; Curran, Dennis P. Chemistry - A European Journal, 1998 , vol. 4, # 1 p. 67 - 83]

Synthetic Studies on Camptothecins. Part 3

[Kuang, Yun-Yan; Niu, Jing-Ze; Chen, Fen-Er Helvetica Chimica Acta, 2010 , vol. 93, # 10 p. 2094 - 2099]

Practical Asymmetric Synthesis of (S)-4-Ethyl-7, 8-dihydro-4-hydroxy-1 H-pyrano [3, 4-f] indolizine-3, 6, 10 (4 H)-trione, a Key Intermediate for the Synthesis of …

[Journal of Organic Chemistry, , vol. 62, # 19 p. 6588 - 6597]

More Articles...