Packed-fiber solid-phase extraction coupled with high performance liquid chromatography–tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products

Wen-Yan Hu, Xue-Jun Kang, Chi Zhang, Jun Yang, Rui Ling, E.-Hu Liu, Ping Li

Index: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 7-13, (2014)

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Abstract

• A method based on packed-fiber solid-phase extraction (PF SPE) has been established for the determination of three estrogenic stilbenes in dairy products. • Samples were pretreated with PF SPE using an electrospun nanofiber cartridge before analysis by RRLC–MS/MS. • Parameters affecting the efficiency of PF SPE, including pH and salt concentration, were investigated and optimized. • The developed method was successfully applied for the determination of stilbenes in 69 milk samples. • The method has proved to be sensitive and cost-effective in stilbene detection.