Dienestrol

Names

[ CAS No. ]:
84-17-3

[ Name ]:
Dienestrol

[Synonym ]:
Retalon
Oestrora
Dinestrol
MFCD00050983
Isodienoestrol
Agaldog
Sexadien
Estroral
Dienoestrol
EINECS 201-519-7
Dinovex
Teserene
Restrol
2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)-

Biological Activity

[Description]:

Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Endocrinology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.129 g/cm3

[ Boiling Point ]:
395.4ºC at 760 mmHg

[ Melting Point ]:
229ºC

[ Molecular Formula ]:
C₁₈H₁₈O₂

[ Molecular Weight ]:
266.33400

[ Flash Point ]:
181.4ºC

[ Exact Mass ]:
266.13100

[ PSA ]:
40.46000

[ LogP ]:
4.60460

[ Index of Refraction ]:
1.4800 (estimate)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0580000

CHEMICAL NAME :: Phenol, 4,4'-(diethylideneethylene)di-

CAS REGISTRY NUMBER :: 84-17-3

LAST UPDATED :: 199512

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H18-O2

MOLECULAR WEIGHT :: 266.36

WISWESSER LINE NOTATION :: QR DYU2&YU2&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 ug/kg

SEX/DURATION :: female 3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 75 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H350-H361

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ RTECS ]:
SL0580000

[ Hazard Class ]:
6.1

Articles

Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples.

J. Chromatogr. A. 1368 , 18-25, (2014)

A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was develo...

Packed-fiber solid-phase extraction coupled with high performance liquid chromatography–tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 7-13, (2014)

• A method based on packed-fiber solid-phase extraction (PF SPE) has been established for the determination of three estrogenic stilbenes in dairy products. • Samples were pretreated with PF SPE using...

Quantitative determination of 26 steroids in eggs from various species using liquid chromatography-triple quadrupole-mass spectrometry.

J. Chromatogr. A. 1356 , 54-63, (2014)

A method for analyzing 26 types of steroids in egg matrix was developed. The method used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in electrospray ionization mode (ESI). T...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.