Convergent synthesis of 4,5-branched inner-core oligosaccharides of lipopoly- and lipooligosaccharides.

Ruiqin Yi, Hirofumi Narimoto, Miku Nozoe, Tsuyoshi Ichiyanagi

Index: Biosci. Biotechnol. Biochem. 79 , 1931-45, (2015)

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Abstract

The convergent synthesis of branched inner-core oligosaccharides of lipopoly- and lipooligosaccharide with a 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) disaccharide acceptor was achieved. The l-glycero-d-manno-heptopyranose (Hep) units for the branched core oligosaccharide Galβ(1-4)Glcβ(1-4)Hep and Hepα(1-3)Hep were prepared from the corresponding Hep building blocks. To obtain 4,5-branched core oligosaccharide structures, the common acceptor Kdoα(2-4)Kdo was glycosylated with the Hep units.