Controllable construction of titanium dioxide-zirconium dioxide@zinc hydroxyfluoride networks in micro-capillaries for bio-analysis.

Gang Wang, Zhongyuan He, Guoying Shi, Hongzhi Wang, Qinghong Zhang, Yaogang Li

Index: J. Colloid. Interface Sci. 446 , 290-7, (2015)

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Abstract

Glass/silica-based flow channels are widely used in capillary electrophoresis and micro-total analysis systems. However, it is almost impossible to achieve controllable fabrication of microstructures with enhanced mixing performance for high-efficiency bio-analysis in confined micro-channels. Here, various morphologies were controllably achieved by tuning the molar ratio of the reaction agents in a confined microchannel. Fluid flow simulation is demonstrated to investigate the structure stability and mixing performance. Multifunctional networks with uniform and deep decoration are fabricated in confined micro-capillaries, owing to the enhanced mixing performance. The modified micro-capillaries exhibit high efficiencies for the selective enrichment of phosphopeptides from traditional model samples. Furthermore, the fabricated micro-capillaries also exhibited high performance in practical applications (for selective enrichments from bovine milk and cancer serum). These outstanding features make the microstructure-modified micro-capillaries promising for bio-analysis. Copyright © 2015 Elsevier Inc. All rights reserved.