Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome.

Eunice Molinar-Toribio, Jara Pérez-Jiménez, Sara Ramos-Romero, Laura Lluís, Vanessa Sánchez-Martos, Núria Taltavull, Marta Romeu, Manuel Pazos, Lucía Méndez, Aníbal Miranda, Marta Cascante, Isabel Medina, Josep Lluís Torres

Index: PLoS ONE 9(8) , e104637, (2014)

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Abstract

SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.