tert-Butyl Hydroperoxide
Names
[ CAS No. ]:
75-91-2
[ Name ]:
tert-Butyl Hydroperoxide
[Synonym ]:
2-hydroperoxy-2-methylpropane
MFCD00002130
EINECS 200-915-7
tert-Butyl hydroperoxide
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
120.4±9.0 °C at 760 mmHg
[ Melting Point ]:
-2.8 °C
[ Molecular Formula ]:
C4H10O2
[ Molecular Weight ]:
90.121
[ Flash Point ]:
35.0±0.0 °C
[ Exact Mass ]:
90.068077
[ PSA ]:
29.46000
[ LogP ]:
1.38
[ Vapour Pressure ]:
7.4±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.399
[ Stability ]:
Stable, but may explode if heated under confinement. Decomposition may be accelerated by traces of metals, molecular sieve or other contaminants. Incompatible with reducing agents, combustible material, acids.
[ Water Solubility ]:
Miscible
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EQ4900000
- CHEMICAL NAME :
- tert-Butylhydroperoxide
- CAS REGISTRY NUMBER :
- 75-91-2
- BEILSTEIN REFERENCE NO. :
- 1098280
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 38
- MOLECULAR FORMULA :
- C4-H10-O2
- MOLECULAR WEIGHT :
- 90.14
- WISWESSER LINE NOTATION :
- QOX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/4H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 87 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 ppm/4H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 246 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 460 uL/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - cyanosis Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/m3/17W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - change in sensation of smell Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 365 mg/kg/7W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 107 mg/m3/17W-I
- TOXIC EFFECTS :
- Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 34 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14730 No. of Facilities: 75 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 433 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14730 No. of Facilities: 266 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 12168 (estimated) No. of Female Employees: 4787 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H242-H302-H304-H311 + H331-H314-H317-H336-H341-H410
[ Precautionary Statements ]:
P210-P234-P280-P301 + P310-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P331-P403 + P233
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R10;R20/21/22;R34;R43;R52/53;R7
[ Safety Phrases ]:
S14-S3/7-S61-S45-S36/37/39-S24-S17-S16-S14A-S26-S62
[ RIDADR ]:
UN 3109 5.2
[ WGK Germany ]:
3
[ RTECS ]:
EQ4900000
[ Packaging Group ]:
II
[ Hazard Class ]:
5.2
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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