Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3′, 4′-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury

S Yap, OL Woodman, PJ Crack, SJ Williams

Index: Yap, Suwan; Woodman, Owen L.; Crack, Peter J.; Williams, Spencer J. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5102 - 5106

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Citation Number: 5

Abstract

3′, 4′-Dihydroxyflavonol (DiOHF) is a cardioprotective flavonol that reduces injury associated with myocardial ischaemia and reperfusion. We hypothesized that the efficacy of DiOHF could be enhanced through its targeting to hypoxic regions of partial reperfusion. ...