Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts
SS Wang, BF Gisin, DP Winter…
Index: Wang,S.-S. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1286 - 1290
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Citation Number: 239
Abstract
A facile procedure for the preparation of a wide variety of esters derived from protected amino acids and peptides under mild conditions is described. The carboxylic acid to be esterified is first titrated to pH 7 with cesium carbonate or cesium bicarbonate and the neutral salt obtained is then allowed to react with different alkyl halides to form the corresponding esters. The reaction is simple, easily scaled up, and proceeds without observable ...
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