Synthesis and biological activity of branched enkephalin analogues
…, N Abissova, N Mishlakova, G Rozentals…
Index: Bobrova, Irina; Abissova, Natalia; Mishlakova, Natalia; Rozentals, Guntis; Chipens, Gunar European Journal of Medicinal Chemistry, 1998 , vol. 33, # 4 p. 255 - 266
Full Text: HTML
Citation Number: 9
Abstract
The synthesis and biological activity of a new type of enkephalin analogs are reported. A series of branched pentapeptides of the enkephalin sequence with replacement of 2-glycine by D-ornithine and branching of the peptide chain in position 2 by attachment of proline, leucine, asparagine or methionine residues to the δ-amino group of D-ornithine were synthesized by classical solution methodology. Analgesic activity of the new analogs was ...
Related Articles:
Synthesis of linear and cyclic peptides related to Met??and Leu??enkephalin
[Van Nispen; Greven Recueil des Travaux Chimiques des Pays Bas, 1982 , vol. 101, # 12 p. 451 - 455]
[Grigor'ev, E. I.; Chernova, S. V. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474]
Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts
[Wang,S.-S. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1286 - 1290]