Synthesis of linear and cyclic peptides related to Met??and Leu??enkephalin

JW van Nispen, HM Greven

Index: Van Nispen; Greven Recueil des Travaux Chimiques des Pays Bas, 1982 , vol. 101, # 12 p. 451 - 455

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Abstract

Abstract The synthesis is described of several peptides containing the sequence Phe-Met. In order to limit enzymatic degradation and to restrict the number of possible conformations they were cyclized with variable ring size. Some unexpected side-reactions were encountered during the synthesis of the linear precursors: partial cleavage of the active ester during removal of the Bocprotecting group, partial cleavage of the Gly-Gly peptide bond ...