Dipeptide renin inhibitors containing a bis [(1-naphthyl) methyl] acetyl group as the N-terminal component
T Nishi, Y Morisawa, Y Lijima, H Koike…
Index: Nishi, Takahide; Morisawa, Yasuhiro; Iijima, Yasuteru; Koike, Hiroyuki; Yabe, Yuichiro Journal of the Chemical Society, Chemical Communications, 1990 , # 23 p. 1672 - 1673
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Abstract
The syntheses and biological activities of potent dipeptide renin inhibitors containing a bis[(l-naphthyl)methyl]acetyl group as the N-terminal component are described. ... The renin-angiotensin system is implicated in the regulation of blood pressure. The first and rate-limiting step of the cascade involves the aspartic proteinase renin; therefore, the development of renin inhibitors is expected to provide effective antihypertensive agents. Numerous ...
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