2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A 1, A 2A and A 3 receptor subtypes
…, JKVFD Künzel, AP IJzerman, GJ Koomen
Index: Wanner, Martin J.; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman; Koomen, Gerrit-Jan Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2141 - 2144
Full Text: HTML
Citation Number: 35
Abstract
The influence of nitro substituents on the properties of adenosine and 1-deazaadenosine was studied. Combination of a nitro group at the 2-position with several N6 substituents such as cyclopentyl and m-iodobenzyl gave a series of analogues with good adenosine receptor affinity, showing directable selectivity for the A1, A2A and A3 adenosine receptor subtypes.
Related Articles:
A New Method for Synthesis of 2-Alkoxyadenosine Analogs
[Sakakibara, Norikazu; Tsuruta, Takashi; Komatsu, Masahiro; Iwai, Masatoshi; Maruyama, Tokumi Heterocycles, 2011 , vol. 83, # 10 p. 2299 - 2311]
A New Method for Synthesis of 2-Alkoxyadenosine Analogs
[Sakakibara, Norikazu; Tsuruta, Takashi; Komatsu, Masahiro; Iwai, Masatoshi; Maruyama, Tokumi Heterocycles, 2011 , vol. 83, # 10 p. 2299 - 2311]
Synthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine
[Bartlett; Cook; Holman; McComas; Nowoswait; Poonian; Baird-Lambert; Baldo; Marwood Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 947 - 954]
2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor
[Ueeda; Thompson; Arroyo; Olsson Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1334 - 1339]
Synthesis of potential anticancer agents. XIV. Ribosides of 2, 6-disubstituted purines
[Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 3738,3741]