2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor

M Ueeda, RD Thompson, LH Arroyo…

Index: Ueeda; Thompson; Arroyo; Olsson Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1334 - 1339

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Citation Number: 87

Abstract

A Langendorff guinea pig heart prepation served for the assay of agonist activity of a series of 24 2-alkoxyadenosines at the A1 and A2 adenosine receptors of, respectively, the atrioventricular node (conduction block) and coronary arteries (vasodilation). Activities are low at the Al receptor and do not show a clear relationship to the size or hydrophobicity of the C-2 substituent. AU the analogues are more potent at the Az receptor, activity varying ...