Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents

…, ZS Li, B Ren, ZM Li, H Dai, LX Zhang, JG Wang

Index: Shang, Jian-Li; Guo, Hui; Li, Zai-Shun; Ren, Biao; Li, Zheng-Ming; Dai, Huan-Qin; Zhang, Li-Xin; Wang, Jian-Guo Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 724 - 727

Full Text: HTML

Citation Number: 8

Abstract

A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin- resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 μg/mL.

Related Articles:

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2, 2′-dithiobisbenzamides

[Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579]

A general and highly regio and stereoselective method for the synthesis of (E)-2-(2-arylvinyl)-3, 1-benzoxathiin-4-ones through palladium–copper catalysis

[Nandi, Bidisha; Kundu, Nitya G. Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1649 - 1655]

Chemistry of sulfenic acids. 7. Reason for the high reactivity of sulfenic acids. Stabilization by intramolecular hydrogen bonding and electronegativity effects

[Davis, Franklin A.; Jenkins, Linda A.; Billmers, Robert L. Journal of Organic Chemistry, 1986 , vol. 51, # 7 p. 1033 - 1040]

Concise Approach to Benzisothiazol-3 (2 H)-one via Copper-Catalyzed Tandem Reaction of o-Bromobenzamide and Potassium Thiocyanate in Water

[Shimizu, Masao; Kikumoto, Hisashi; Konakahara, Takeo; Gama, Yasuo; Shibuya, Isao Heterocycles, 1999 , vol. 51, # 12 p. 3005 - 3012]

Electrosynthesis of fluorinated benzo [b] thiophene derivatives

[Yin, Bin; Inagi, Shinsuke; Fuchigami, Toshio Synlett, 2011 , # 9 p. 1313 - 1317]

More Articles...