A general and highly regio and stereoselective method for the synthesis of (E)-2-(2-arylvinyl)-3, 1-benzoxathiin-4-ones through palladium–copper catalysis

B Nandi, NG Kundu

Index: Nandi, Bidisha; Kundu, Nitya G. Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1649 - 1655

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Abstract

In the C-arylation step, a combination of bis(triphenylphosphine)palladium(II) dichloride (3.5 mol%) (catalyst) and CuI (6 mol%) (co-catalyst) was the most desired catalytic system. It was found that in the absence of bis(triphenylphosphine)palladium(II) dichloride, no disubstituted alkynes were formed. We have also explored other palladium catalysts, eg (PPh 3 ) 4 Pd, Pd(OAc) 2 along with PPh 3 , and found that yields were not appreciable. Copper(I) ...

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