A one-pot synthesis of substituted salicylnitriles
HF Anwar, TV Hansen
Index: Anwar, Hany F.; Hansen, Trond Vidar Tetrahedron Letters, 2008 , vol. 49, # 28 p. 4443 - 4445
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Citation Number: 15
Abstract
Phenols were converted to salicylaldehydes with paraformaldehyde, MgCl2–Et3N in THF, and subsequent treatment with aqueous ammonia gave the corresponding imines which were oxidized with IBX to the desired salicylnitriles. The sequence of reactions was conveniently carried out as a one-pot procedure under mild conditions.
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