Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers
T Ohwada, T Nonomura, K Maki, K Sakamoto…
Index: Ohwada, Tomohiko; Nonomura, Taro; Maki, Keisuke; Sakamoto, Kazuho; Ohya, Susumu; Muraki, Katsuhiko; Imaizumi, Yuji Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3971 - 3974
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Citation Number: 41
Abstract
We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K+ channels (BK channels). Structure–activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability.
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