Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives
YM Cui, E Yasutomi, Y Otani, K Ido, T Yoshinaga…
Index: Cui, Yong-Mei; Yasutomi, Eriko; Otani, Yuko; Ido, Katsutoshi; Yoshinaga, Takashi; Sawada, Kohei; Ohwada, Tomohiko Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 24 p. 8642 - 8659
Full Text: HTML
Citation Number: 25
Abstract
Oxime ether derivatives at the benzylic position of unsubstituted, dichloro, trichloro, and monobromo derivatives of the aromatic C-ring of dehydroabietic acid and podocarpic acid were synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKα channels. Detailed SAR analysis showed that the oximation was particularly effective in the cases of dehydroabietic acid derivatives, and some of these ...
Related Articles:
Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid
[Pertino, Mariano Walter; Verdugo, Valery; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo Molecules, 2014 , vol. 19, # 2 p. 2523 - 2535]
[Ohwada, Tomohiko; Nonomura, Taro; Maki, Keisuke; Sakamoto, Kazuho; Ohya, Susumu; Muraki, Katsuhiko; Imaizumi, Yuji Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3971 - 3974]
Reactions of abietic acid methyl ester with m-chloroperbenzoic acid
[Tetrahedron, , vol. 42, # 2 p. 573 - 582]
[Matsushita, Yoh-ichi; Sugamoto, Kazuhiro; Iwakiri, Yoshihisa; Yoshida, Satoru; Chaen, Takehito; Matsui, Takanao Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3931 - 3934]
[Tetrahedron, , vol. 63, # 45 p. 11204 - 11212]