Tetrahedron letters

Three-step synthesis of 4-(2′-hydroxyethyl) azetidin-2-one and its substituted derivatives from 4-acetoxy-2-pyridones

C Kaneko, T Naito, A Saito

Index: Kaneko, Chikara; Naito, Toshihiko; Saito, Akemi Tetrahedron Letters, 1984 , vol. 25, # 15 p. 1591 - 1594

Full Text: HTML

Citation Number: 8

Abstract

Abstract 4-(2'-Hydroxyethyl) azetidin-2-one, an important synthetic intermediate for carbapenem, and its substituted derivatives have been synthesized from 4-acetoxy-2- pyridones by photolysis, catalytic hydrogenation, followed by basic hydrolysis in the presence of sodium borohydride.

Related Articles:

Synthetic study of carbapenem antibiotics I.(±)-2-cyclopropyl-6-(1′-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid

[Shih, David H.; Fayter, Judith A.; Christensen, Burton G. Tetrahedron Letters, 1984 , vol. 25, # 16 p. 1639 - 1642]

rel-(1R, 4R, 5S)-5-hydroxy-3-oxo-2-azabicyclo [2.2. 0] hexane, a stable synthetic equivalent of 4-(2-oxoethyl) azetidin-2-one

[Katagiri, Nobuya; Sato, Masayuki; Naito, Toshihiko; Muto, Makoto; Sakamoto, Toshiyuki; et al. Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5665 - 5668]

More Articles...