Tetrahedron letters

Synthetic study of carbapenem antibiotics I.(±)-2-cyclopropyl-6-(1′-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid

DH Shih, JA Fayter, BG Christensen

Index: Shih, David H.; Fayter, Judith A.; Christensen, Burton G. Tetrahedron Letters, 1984 , vol. 25, # 16 p. 1639 - 1642

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Citation Number: 7

Abstract

Abstract A synthetic scheme extensively utilizing silylation-desilylation reactions to achieve the total synthesis of 2, 6-substituted carbapenem antibiotics from readily available azetidinones is reported. An epimeric pair of new 2, 6-substituted carbapenems,(±)-2- cyclopropyl-6-(1′-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acids were synthesized.

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