Aluminum chloride-promoted aminolysis of N-tosyl lactams
E Bon, DCH Biggs, G Bertrand…
Index: Bon, Eric; Bigg, Dennis C. H.; Bertrand, Guy Journal of Organic Chemistry, 1994 , vol. 59, # 7 p. 1904 - 1906
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Citation Number: 13
Abstract
The ring-opening reactions of lactams by nucleophilic attack provide a convenient route to w- substituted carboxylic acid derivatives. Owing to the low reactivity of the endocyclic carbonyl, the presence of an electronwithdrawing group on the lactam nitrogen is generally necessary, and N-acyl or N-alkoxycarbonyl lactams may be cleaved by hydroxide" and alkoxide ions, k7 hydrazine! Grignard reagents, a10 organolithium compounds, 9J1 and ...
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