Palladium-catalyzed carbonylation of homoallylic amine derivatives in the presence of a copper co-catalyst

T Mizutani, Y Ukaji, K Inomata

Index: Mizutani, Takanori; Ukaji, Yutaka; Inomata, Katsuhiko Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 6 p. 1251 - 1256

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Citation Number: 21

Abstract

γ-Lactams were synthesized from N-tosylhomoallylamines by a carbonylation reaction catalyzed by palladium and copper salts under the normal pressure of CO and O 2 at room temperature. Monocarbonylation proceeded by the use of [PdCl 2 (CH 3 CN) 2] and CuCl 2 to afford 3-methyl-2-pyrrolidones, while the use of PdCl 2 and CuCl switched the reaction from monocarbonylation to dicarbonylation to produce alkyl 2-oxopyrrolidine-3-acetate in ...