Synthesis of a novel series of 4, 4-disubstituted 2, 3, 4, 7-tetrahydroazepines
M Barberis, P García-Losada, S Pleite, JR Rodríguez…
Index: Barberis, Mario; Garcia-Losada, Pablo; Pleite, Sehila; Rodriguez, Juan Ramon; Soriano, Jose Francisco; Mendiola, Javier Tetrahedron Letters, 2005 , vol. 46, # 29 p. 4847 - 4850
Full Text: HTML
Citation Number: 11
Abstract
A general, simple and straightforward strategy for the synthesis of a novel series of 4, 4- disubstituted 2, 3, 4, 7-tetrahydroazepines is described. This route involves a one-pot Wittig olefination/N-allylation process on a five-membered hemi-aminal followed by a final ring closing metathesis reaction.
Related Articles:
[Mizutani, Takanori; Ukaji, Yutaka; Inomata, Katsuhiko Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 6 p. 1251 - 1256]
Cyclization cycloaddition cascades for the construction of azapolycyclic ring systems
[Padwa, Albert; Kissell, William S.; Eidell, Cheryl K. Canadian Journal of Chemistry, 2001 , vol. 79, # 11 p. 1681 - 1693]
[Mizutani, Takanori; Ukaji, Yutaka; Inomata, Katsuhiko Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 6 p. 1251 - 1256]
Aluminum chloride-promoted aminolysis of N-tosyl lactams
[Bon, Eric; Bigg, Dennis C. H.; Bertrand, Guy Journal of Organic Chemistry, 1994 , vol. 59, # 7 p. 1904 - 1906]
Carbamoyl radicals from Se-phenylselenocarbamates: Intramolecular additions to alkenes
[Rigby, James H.; Danca, Diana M.; Horner, John H. Tetrahedron Letters, 1998 , vol. 39, # 46 p. 8413 - 8416]