A novel series of urea-based peptidomimetic calpain inhibitors
ML Sanders, IO Donkor
Index: Sanders, M. Lee; Donkor, Isaac O. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1965 - 1968
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Citation Number: 10
Abstract
A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.
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