Monoalkylation of primary amines and N-sulfinylamides

…, A Parra, J Aleman, F Yuste, VM Mastranzo

Index: Garcia Ruano, Jose Luis; Parra, Alejandro; Aleman, Jose; Yuste, Francisco; Mastranzo, Virginia M. Chemical Communications, 2009 , # 4 p. 404 - 406

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Citation Number: 18

Abstract

General synthetic methods for the preparation of dialkylamines 3 are usually included in some of these three strategies: reductive amination of aldehydes and ketones, 4 alkylation of primary amines with alkyl halides, 5 and alkylation reactions using transition metals. 6 All of them have disadvantages which determine that they cannot be considered as a general method. Thus, reductive amination requires the use of strong reducing reagents that are not compatible with the ...