Synlett

Chemical Synthesis with Inductively Heated Copper Flow Reactors

S Ceylan, T Klande, C Vogt, C Friese, A Kirschning

Index: Ceylan, Sascha; Klande, Tobias; Vogt, Carla; Friese, Carsten; Kirschning, Andreas Synlett, 2010 , # 13 p. 2009 - 2013

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Citation Number: 9

Abstract

Abstract Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1, 3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1, 2, 3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular CO coupling of 2′- bromobiphenyl-2-carboxylic acid.

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