A flow microreactor system enables organolithium reactions without protecting alkoxycarbonyl groups
A Nagaki, H Kim, Y Moriwaki, C Matsuo…
Index: Nagaki, Aiichiro; Kim, Heejin; Moriwaki, Yuya; Matsuo, Chika; Yoshida, Jun-Ichi Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11167 - 11177
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Citation Number: 50
Abstract
Abstract A flow microreactor system consisting of micromixers and microtube reactors provides an effective tool for the generation and reactions of aryllithiums bearing an alkoxycarbonyl group at para-, meta-, and ortho-positions. Alkyl p-and m-lithiobenzoates were generated by the I/Li exchange reaction with PhLi. The Br/Li exchange reactions with sBuLi were unsuccessful. Subsequent reactions of the resulting aryllithiums with ...
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