Condensation reactions. II. Alkylidene cyanoacetic and malonic esters

AC Cope, CM Hofmann, C Wyckoff…

Index: Cope et al. Journal of the American Chemical Society, 1941 , vol. 63, p. 3455

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Citation Number: 179

Abstract

A method for condensing aliphatic ketones with cyanoacetic ester was reported recently,'in which the reactants were heated in the presence of acetamide and acetic acid, the water formed in the condensation being removed continuously by slow distillation of the acetic acid. The method is not convenient for condensing ethyl cyanoacetate with low boiling ketones, which are removed during the distillation and must be used in large excess, or for ...