Novel Process for the Synthesis of Class I Antiarrhythmic Agent (±)-Cibenzoline and Its Analogs
AR Gholap, V Paul, KV Srinivasan
Index: Gholap, Atul R.; Paul, Vincent; Srinivasan, Kumar V. Synthetic Communications, 2008 , vol. 38, # 17 p. 2967 - 2982
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Citation Number: 4
Abstract
Abstract Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra- substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β- hydroxynitrile intermediate 2′ followed by the elimination of hydroxyl group respectively. ...
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