Synthesis of hetero-and carbocycles by nucleophilic substitution at sp 2 carbon
H Miyauchi, S Chiba, K Fukamizu, K Ando, K Narasaka
Index: Miyauchi, Hironori; Chiba, Shunsuke; Fukamizu, Koji; Ando, Kaori; Narasaka, Koichi Tetrahedron, 2007 , vol. 63, # 26 p. 5940 - 5953
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Citation Number: 23
Abstract
Vinylic halides having alcohol, sulfonamide, active methine, and thiol moieties as nucleophiles cyclize to hetero-and carbocycles by intramolecular nucleophilic substitution at the sp2 carbon centers. The density functional theory calculations suggest that the cyclization proceeds through SN2-type substitution (the in-plane vinylic nucleophilic substitution, SNVσ), when vinyl halides are substituted with oxygen, nitrogen, and carbon ...
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