Microwave-assisted, one-pot reaction of pyridines, α-bromoketones and ammonium acetate: an efficient and simple synthesis of imidazo [1, 2-a]-pyridines
…, A Mohamadi, E Sheikhi, S Ansari, HR Bijanzadeh
Index: Adib, Mehdi; Mohamadi, Ali; Sheikhi, Ehsan; Ansari, Samira; Bijanzadeh, Hamid Reza Synlett, 2010 , # 11 p. 1606 - 1608
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Citation Number: 21
Abstract
Abstract A novel and efficient synthesis of imidazo [1, 2-a] pyridines is described. N- Phenacylpyridinium bromides, which were prepared in situ from the addition of pyridines to α-bromoketones, undergo nucleophilic addition of ammonium acetate under microwave irradiation and solvent-free conditions to afford the corresponding imidazo [1, 2-a] pyridines in excellent yields.
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