Aerobic Multicomponent Tandem Synthesis of 3??Sulfenylimidazo [1, 2??a] pyridines from Ketones, 2??Aminopyridines, and Disulfides

W Ge, X Zhu, Y Wei

Index: Ge, Wenlei; Zhu, Xun; Wei, Yunyang European Journal of Organic Chemistry, 2013 , # 27 p. 6015 - 6020

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Citation Number: 26

Abstract

Abstract An aerobic CeCl 3· 7H 2 O/NaI-catalyzed C–H functionalization reaction was developed for the synthesis of 3-sulfenylimidazo [1, 2-a] pyridines from easily available ketones, 2-aminopyridines, and disulfides without DMSO or peroxide as an oxidant. This three-component tandem reaction process involves the formation of imidazo [1, 2-a] pyridines followed by Friedel–Crafts sulfenylation in one pot under mild conditions. Both ...