Practical Synthesis of PGI2 Agonist: Resolution–Inversion–Recycle Approach of Its Chiral Intermediate

…, A Kanda, S Moriki, Y Baba, N Hashimoto…

Index: Ohigashi, Atsushi; Kanda, Atsushi; Moriki, Shigeru; Baba, Yukihisa; Hashimoto, Norio; Okada, Minoru Organic Process Research and Development, 2013 , vol. 17, # 4 p. 658 - 665

Full Text: HTML

Citation Number: 1

Abstract

Practical synthesis of ((2 R)-5-benzyloxy-2-hydroxy-1, 2, 3, 4-tetrahydronaphth-2-yl) methanol ((R)-7b), a key chiral intermediate for the synthesis of the novel PGI2 agonist,(R)-[6- [(diphenylcarbamoyloxy) methyl]-6-hydroxy-5, 6, 7, 8-tetrahydronaphthalen-1-yloxy] acetic acid (1), was achieved via optical resolution by diastereoselective crystallization of ester derivative 18 of racemic (5-benzyloxy-2-hydroxy-1, 2, 3, 4-tetrahydronaphth-2-yl) ...

Related Articles:

Total synthesis of dysiherbaine

[Kappes, Dag; Gerlach, Hans Synthetic Communications, 1990 , vol. 20, # 4 p. 581 - 587]

The Preparation of Optically Pure 7??Oxabicyclo [2.2. 1] hept??2??ene Derivatives. The CD Spectrum of (+)??(1R)??7??Oxabicyclo [2.2. 1] hept??5??en??2??one

[Helvetica Chimica Acta, , vol. 66, # 6 p. 1865 - 1871]

Preparation of (-)-(1 S, 4 R)-Camphanoyl Chloride [2-Oxabicyclo [2.2. 1] heptane-1-carbonyl Chloride, 4, 7, 7-Trimethyl-3-oxo,(1S)-]

[Synthetic Communications, , vol. 20, # 4 p. 581 - 587]

Practical Synthesis of PGI2 Agonist: Resolution–Inversion–Recycle Approach of Its Chiral Intermediate

[Organic Process Research and Development, , vol. 17, # 4 p. 658 - 665]

The Preparation of Optically Pure 7??Oxabicyclo [2.2. 1] hept??2??ene Derivatives. The CD Spectrum of (+)??(1R)??7??Oxabicyclo [2.2. 1] hept??5??en??2??one

[Helvetica Chimica Acta, , vol. 66, # 6 p. 1865 - 1871]

More Articles...