Catalytic asymmetric synthesis of optically active 2-alkanols via hydrosilylation of 1-alkenes with a chiral monophosphine-palladium catalyst

Y Uozumi, T Hayashi

Index: Uozumi, Yasuhiro; Hayashi, Tamio Journal of the American Chemical Society, 1991 , vol. 113, # 26 p. 9887 - 9888

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Citation Number: 282

Abstract

Catalytic asymmetric functionalization of simple prochiral olefis is an important goal in synthetic organic chemistry.'q2 We report here the first successful conversion of alkyl- substituted terminal olefins into optically active secondary alcohols (> 94% ee), 3 which is realized by palladium-catalyzed asymmetric hydrosilylation in the presence of a new chiral monodentate phosphine ligand (MOP, 1) followed by oxidation of the carbonsilicon bond4 ...