Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5, 11-Dihydro-5-methyl-11-methylene-6 H- …
A Aoyama, K Endo-Umeda, K Kishida…
Index: Journal of Medicinal Chemistry, , vol. 55, # 17 p. 7360 - 7377
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Citation Number: 17
Abstract
... Journal of Medicinal Chemistry. ... serious hypertriglyceridemia because genes involved in lipid synthesis, such as srebp-1c and fas, have LXRE in their promoter region and are activated by LXR transactivational agonists.(8) This is a major barrier to medical application of LXR ...
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