Chemoenzymatic Route to S-Betaxolol
YH Li, LH Huang, HM Liu
Index: Li, Yong-Hong; Huang, Li-Hua; Liu, Hong-Min Synthetic Communications, 2011 , vol. 41, # 16 p. 2468 - 2474
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Citation Number: 5
Abstract
Abstract An efficient chemoenzymatic route to S-betaxolol is reported. A strain (Rhodotorula mucilaginosa DQ832198) screened from soil was used as biocatalyst for the kinetic resolution of the key acetylated intermediates. Excellent enantiomeric excess (ee> 99%)
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