Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
M Muthukrishnan, DR Garud, RR Joshi, RA Joshi
Index: Muthukrishnan; Garud, Dinesh R.; Joshi Tetrahedron, 2007 , vol. 63, # 8 p. 1872 - 1876
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Citation Number: 30
Abstract
Hypertension is a growing medical concern worldwide. With an increasing number of patients suffering from hypertension every year, the use of antihypertensive medications such as β-blockers has increased. β-Blockers 1, 1a and 1b are a group of compounds that competitively inhibit the effects of catecholamines at β-adrenergic receptors and have a diverse range of clinical applications in the treatment of cardiovascular disorders. 2, 2a, 2b and 2c Metoprolol (1) and betaxolol ...
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Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
[Tetrahedron, , vol. 63, # 8 p. 1872 - 1876]
Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
[Tetrahedron, , vol. 63, # 8 p. 1872 - 1876]