Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin
…, CF Lima, MF Proença, C Pereira-Wilson
Index: Dias, Tatiana A.; Duarte, Cecilia L.; Lima, Cristovao F.; Proenca, M. Fernanda; Pereira-Wilson, Cristina European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 500 - 510
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Citation Number: 29
Abstract
Abstract A series of chalcone and flavonol derivatives were synthesized in good yield by an eco-friendly approach. A pharmacological evaluation was performed with the human colorectal carcinoma cell line HCT116 and revealed that the anticancer activity of flavonols was higher when compared with that of the respective chalcone precursors. The antiproliferative activity of halogenated derivatives increases as the substituent in the 3-or ...
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