Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives

Z Wang, P Wei, X Xizhi, Y Liu, L Wang…

Index: Wang, Ziwen; Wei, Peng; Xizhi, Xu; Liu, Yuxiu; Wang, Lizhong; Wang, Qingmin Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 35 p. 8544 - 8551

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Citation Number: 12

Abstract

On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1–12 and 18–50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which ...