One??Pot Transformation of Carboxylic Acids into Nitriles

K Miyagi, K Moriyama, H Togo

Index: Miyagi, Kotaro; Moriyama, Katsuhiko; Togo, Hideo European Journal of Organic Chemistry, 2013 , # 26 p. 5886 - 5892

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Citation Number: 3

Abstract

Abstract A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K 2 CO 3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1, 3-diiodo-5, 5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic ...