2, 3-disubstituted benzofuran and indole by copper-mediated CC bond extension reaction of 3-zinciobenzoheterole
M Nakamura, L Ilies, S Otsubo, E Nakamura
Index: Nakamura, Masaharu; Ilies, Laurean; Otsubo, Saika; Nakamura, Eiichi Organic Letters, 2006 , vol. 8, # 13 p. 2803 - 2805
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Citation Number: 101
Abstract
A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl2 produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2, 3-disubstituted benzofurans and indoles.
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