N-alkylation of pyrrole, indole, and several other nitrogen heterocycles using potassium hydroxide as a base in the presence of polyethylene glycols or their dialkyl …
K Sukata
Index: Sukata, Kazuaki Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 1 p. 280 - 284
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Citation Number: 57
Abstract
The alkylation of pyrrole and indole in aqueous potassium hydroxide-organic two-phase systems in the presence of polyethylene glycols (PEG) or their dialkyl ethers (PEG-ether) as phase transfer catalysts (PTC) gave substantial quantities of the C-alkylated and C, N- polyalkylated products as well as the N-alkylated products. This fact is similar to that obtained in the presence of quaternary ammonium salts as PTC. In powdered potassium ...
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