Synthesis, properties, and mass-spectrometric fragmentation of 2-thio derivatives of 3-arylquinazolin-4-ones

YA Azev, BV Golomolzin, T Dyulcks, NA Klyuev…

Index: Azev; Golomolzin; Dyulcks; Klyuev; Yatluk Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 3 p. 356 - 361

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Abstract

Abstract We have studied the reactions of alkylation, oxidation, and hydrolysis of 3-aryl-2- thioxoquinazolin-4-ones. Alkylation in an alkaline medium occurs exclusively at the sulfur atom. Oxidation by hydrogen peroxide leads to formation of 3-arylquinazoline-2, 4-diones. The latter are also obtained in base or acid hydrolysis of the synthesized S-alkyl derivatives. When 3-aryl-2-thioxoquinazolin-4-ones are reacted with iodine, we obtain the disulfides, ...

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