Convenient preparation of N??substituted 2??amino??4H??3, l??benzoxazin??4??ones and 3??substituted 2, 4 (1H, 3H)??quinazolinediones

EP Papadopoulos, CD Torres

Index: Papadopoulos, E. P.; Torres, C. D. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 269 - 272

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Citation Number: 43

Abstract

Abstract Room temperature treatment of 2-(3-arylureido) benzoic acids (1) and methyl 2-(3- alkyl-, or 3-arylureido)-benzoates (2) with concentrated sulfuric acid leads to N-substituted 2- amino-4H-3, l-benzoxazin-4-ones (3) in generally very good yields. The isomeric 3- substituted 2, 4 (1H, 3H)-quinazolinediones (4) are conveniently made in high yield by the action of aqueous-ethanolic sodium hydoxide on 2.

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