3-(1, 1-Dioxo-2 H-(1, 2, 4)-benzothiadiazin-3-yl)-4-hydroxy-2 (1 H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

…, N Liu, RM Keenan, J Lin-Goerke…

Index: Reddy, Ch. K.; Reddy, P. S. N.; Ratnam, C. V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 882 - 883

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Citation Number: 136

Abstract

... Journal of Medicinal ... figure Scheme 2 a,b. a Conditions: (a) COCl 2 , Na 2 CO 3 , toluene or (Cl 3 CO) 2 CO, K 2 CO 3 , EtOAc; (b) NaH, R 1 X, DMF or R 1 OH, Ph 3 P, DIAD; (c) R 1 NH 2 , CuBr 2 , K 2 CO 3 , THF or DMF; (d) (1) ClCOCH 2 CO 2 Et, pyridine, CH 2 Cl 2 ; (2) 10 ...